Welcome to the Center for Functional Cancer Epigenetics
Our mission is to explore the key role that epigenetic alterations and abnormal transcriptional regulation play in the development and progression of cancer. A better understanding of these alterations will reveal novel therapeutic vulnerabilities that are potentially targetable.
As a strategic Center at the Dana-Farber Cancer Institute, the CFCE collaborates with internal and external research laboratories as well as companies, to perform molecular profiling of cancer cells in bulk and at a single-cell resolution. To that aim, CFCE capabilities combine state-of-the-art methodologies with in-depth bioinformatic analyses. CFCE is particularly experienced in chromatin analysis of clinical samples and has developed specific technology for the interrogation of Formalin-Fixed and Paraffin-embedded (FFPE) human tissues. Our capabilities are contributing to the understanding of key aspect of cancer biology including cancer heterogeneity, clonal evolution and therapeutic response. Our collaborations extend to a number of areas including drug resistance, immuno-oncology, targeted therapy, and hormone-dependent cancers among others.